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Index > Protein center > MMEL1(Gene name) > Human
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  • MMEL1 (Gene name),
  • Membrane metallo-endopeptidase-like 1 (Protein name ),  MMEL1_HUMAN from NCBI database.
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  • Gene name:
    MMEL1(MELL1;MMEL2;NEP2);
    Protein name:
    Membrane metallo-endopeptidase-like 1;
    Alternative:
    NEP2(m);Membrane metallo-endopeptidase-like 2;Neprilysin-2(NEP2;NL2);Neprilysin II(NEPII);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificiy with MME and cleaves peptides at the same amide bond.
    Subcellular Location:
    Membrane Single-pass type II membrane protein Secreted A secreted form produced by proteollytic cleavage also exists.
    Protein Attributes:
    Sequence length:
    779
    Sequence:
    50:
    MGKSEGPVGM | VESAGRAGQK | RPGFLEGGLL | LLLLLVTAAL | VALGVLYADR | 
    100:
    RGKQLPRLAS | RLCFLQEERT | FVKRKPRGIP | EAQEVSEVCT | TPGCVIAAAR | 
    150:
    ILQNMDPTTE | PCDDFYQFAC | GGWLRRHVIP | ETNSRYSIFD | VLRDELEVIL | 
    200:
    KAVLENSTAK | DRPAVEKART | LYRSCMNQSV | IEKRGSQPLL | DILEVVGGWP | 
    250:
    VAMDRWNETV | GLEWELERQL | ALMNSQFNRR | VLIDLFIWND | DQNSSRHIIY | 
    300:
    IDQPTLGMPS | REYYFNGGSN | RKVREAYLQF | MVSVATLLRE | DANLPRDSCL | 
    350:
    VQEDMVQVLE | LETQLAKATV | PQEERHDVIA | LYHRMGLEEL | QSQFGLKGFN | 
    400:
    WTLFIQTVLS | SVKIKLLPDE | EVVVYGIPYL | QNLENIIDTY | SARTIQNYLV | 
    450:
    WRLVLDRIGS | LSQRFKDTRV | NYRKALFGTM | VEEVRWRECV | GYVNSNMENA | 
    500:
    VGSLYVREAF | PGDSKSMVRE | LIDKVRTVFV | ETLDELGWMD | EESKKKAQEK | 
    550:
    AMSIREQIGH | PDYILEEMNR | RLDEEYSNLN | FSEDLYFENS | LQNLKVGAQR | 
    600:
    SLRKLREKVD | PNLWIIGAAV | VNAFYSPNRN | QIVFPAGILQ | PPFFSKEQPQ | 
    650:
    ALNFGGIGMV | IGHEITHGFD | DNGRNFDKNG | NMMDWWSNFS | TQHFREQSEC | 
    700:
    MIYQYGNYSW | DLADEQNVNG | FNTLGENIAD | NGGVRQAYKA | YLKWMAEGGK | 
    750:
    DQQLPGLDLT | HEQLFFINYA | QVWCGSYRPE | FAIQSIKTDV | HSPLKYRVLG | 
    779:
    SLQNLAAFAD | TFHCARGTPM | HPKERCRVW
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Membrane metallo-endopeptidase-like 1
    Cat.:
    E2033h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Membrane metallo-endopeptidase-like 1
    Cat.:
    E2033r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Membrane metallo-endopeptidase-like 1
    Cat.:
    E2033m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Membrane metallo-endopeptidase-like 1
    Cat.:
    U2033h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Membrane metallo-endopeptidase-like 1
    Cat.:
    U2033m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Membrane metallo-endopeptidase-like 1
    Cat.:
    U2033r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Membrane metallo-endopeptidase-like 1
    Cat.:
    P2033Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Membrane metallo-endopeptidase-like 1
    Cat.:
    P2033Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Membrane metallo-endopeptidase-like 1
    Cat.:
    P2033Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Membrane metallo-endopeptidase-like 1
    Monoclonal Antibody for Human Membrane metallo-endopeptidase-like 1
    Monoclonal Antibody for Human Membrane metallo-endopeptidase-like 1
    Protein for Human Membrane metallo-endopeptidase-like 1
    Protein for Human Membrane metallo-endopeptidase-like 1
    Protein for Human Membrane metallo-endopeptidase-like 1

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    References
    1. 1.
      "Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family."
      Bonvouloir N. , Lemieux N. , Crine P. , Boileau G. , DesGroseillers L.
      DNA Cell Biol.20:493-498(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    2. 2.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT THR-518
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